It's kinda cliche, but my bet is The Weeknd as his music is something very shocking-His music is nothing similar to that I have ever heard of. Its a sensational combination of R&B music and synth beats.
CBC Radio 3 has a very interesting post about their prediction. They analyzed it from the very statistical point of view, gathering data from press and the past trends. Click here to check out the post.
You can witness the award on MuchMusic from 8p.m Eastern or join the Gala Screening party at Drake Hotel.